Veronicastrum sibiricum (L.) Pennell extract alleviates inflammation‑induced muscle atrophy through NLRP3 inflammasome regulation and mitochondrial function restoration
Year: 2026
Type: article
Abstract: to mimic the disease state of sepsis. H&E staining was carried out to examine the cross‑section of muscle tissues. ELISAs were carried out to investigate cytokine expression in mouse serum. Significant muscle atrophy was observed under the LPS‑induced inflammatory state, whereas VSE decreased the expression levels of the muscle atrophy markers muscle‑specific RING finger protein 1 and muscle atrophy F‑box protein. Furthermore, VSE reduced the expression levels of factors involved in the NLRP3 inflammasome, such as NLRP3, GSDMD, cleaved‑GSDMD, caspase‑1 and cleaved‑caspase‑1. Additionally, the present study revealed that VSE improved mitochondrial function.
Source: Molecular Medicine Reports
Authors: Eunhye Lee, Minjeong Kwon, Ju-Ock Nam
Institution: Kyungpook National University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7140548098
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