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Comparison of Respiratory Syncytial Virus (RSV)–Specific Antibody Durability in Pregnant/Postpartum Individuals and Older Adults After RSV Vaccination

Year: 2026
Type: article
Study design: Observational Study
Abstract: Respiratory syncytial virus (RSV) vaccination is recommended in pregnancy. Limited data exist regarding antibody (Ab) durability to inform revaccination timing. We conducted prospective cohort studies among pregnant and older adults after first RSV vaccination in 2023-2024. Longitudinal samples from 50 pregnant (36 vaccinated) and 16 vaccinated older adults were collected until 12-15 months after vaccination and tested for RSV binding and neutralizing Ab. Mean Ab levels 12-15 months after vaccination were similar between vaccinated maternal and older adult participants (P = .73), suggesting Ab durability up to 1 year after maternal RSV vaccination. RSV binding and neutralizing Ab titers were strongly correlated (R = .73).
DOI: 10.1093/infdis/jiag111
Authors: Alisa Kachikis, Collrane Frivold, Mindy Pike, Jonathan C Reed, Jennifer E Stolarczuk, Kittredge McVey, Erica Clark, Clarice Mauer, Sandra McAteer, Ioana Maria Saidac, Alex Harteloo, Marco Carone, Grace Marshall, Linda O Eckert, Alexander L Greninger, Janet A Englund, Helen Y Chu
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,763
OpenAlex ID: W7140607175
FWCI:
Cites: 14
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