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Stimulation of basolateral calcium-sensing receptor inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule

Year: 2026
Type: article
Abstract: It is not known whether CaSR also inhibits Kir4.1/Kir5.1 in the native DCT. We have now used the patch-clamp experiments to directly demonstrate that the stimulation of CaSR in the basolateral membrane is able to inhibit Kir4.1/Kir5.1 in the mouse DCT and depolarize the DCT membrane potential. We speculate that the stimulation of CaSR-induced inhibition of Kir4.1/Kir5.1 may play a role in decreasing kidney Ca 2+ excretion during hypocalcemia.
DOI: 10.1152/ajprenal.00339.2025
Authors: Junlin Wang, Jiawen Zhang, Shumin Kong, Ping Ma, Zhen Zhang, Lijun Wang, Wen-Hui Wang, Rui-Min Gu
Institutions: Heilongjiang University of Chinese Medicine, Soochow University, Second Affiliated Hospital of Soochow University, Suzhou University, Harbin Medical University, New York Medical College
Language: English
Open Access status: hybrid
OpenAlex ID: W7140632626
FWCI: 1.842
Cites: 36
Cited by: 1
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