Work

Clonal tracing of rare anal metastasis in esophageal squamous cell carcinoma: a case report with whole-exome sequencing and multimodal therapy

Year: 2026

Type: article

Abstract: Esophageal squamous cell carcinoma (ESCC) shows considerable variation in incidence across different regions and is affected by various risk factors, including smoking and HPV infection. This article presents a rare case of ESCC that metastasized to the anal region, illustrating the effectiveness of whole-exome sequencing and clonal evolution analysis in identifying the origins of the metastasis. The findings reveal distinct clonal characteristics between the primary tumor and the metastatic site. This underscores the importance of molecular profiling for developing effective treatment strategies.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2026.1727070

Authors: Yuzhu Jiang, Yu Pu, Zhou Huang, Qin Pei, Mengxia Li, Mingfang Xu

Institutions: Army Medical University, Daping Hospital, Second Affiliated Hospital of Chongqing Medical University

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801