Work

Associations of urinary isoprostanes with structural and load-dependent arterial stiffness: the Multi-Ethnic Study of Atherosclerosis

Year: 2026

Type: article

Study design: Observational Study

Abstract: We examined cross-sectional and longitudinal associations of urinary isoprostanes with carotid T-PWV, and its associated mechanisms (S-PWV and LD-PWV), in a multiethnic cohort of adults. Higher isoprostanes were cross-sectionally associated with carotid artery stiffness driven by structural remodeling in adults who self-reported taking angiotensin-II acting medications or self-identified as White. No associations were observed with isoprostanes and carotid stiffness a decade later in the entire analytic sample. Oxidative stress may augment the risk of structural remodeling in select populations.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00971.2025

Authors: Theodore M. DeConne, Petra Buzkova, Ryan Pewowaruk, Bruce M. Psaty, Adam D. Gepner, Joseph A. Delaney, Timothy M. Hughes, Nels C. Olson

Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Washington, University of Wisconsin–Madison, William S. Middleton Memorial Veterans Hospital, University of Vermont

Language: English

Topic: Cardiovascular Health and Disease Prevention

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences

Awards: G1261793039, MESA, G1276754516, G1539384734, G1640378483, G1803853571, G2144938473, G22458031, MESA, G2580996367, MESA, G2837638605, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3188439488, G3570589137, MESA, Heart Failure with Preserved EF: Female sex-hormones and cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4563812999, G4659638920, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G5108002584, G514410172, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, Institute for Clinical and Translational Research, MESA, G66341962, MESA, G78770644, Clinical and Translational Science Award, G8761005068, Translational Training in Aging and Alzheimer’s Disease Related Disorders, Alzheimer's Disease Research Center, G94668252, G991334795

OpenAlex ID: W7140638877

FWCI:

Cites: 70

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