Work

Levodopa-Induced Oculogyric Crisis in Multiple System Atrophy

Year: 2026

Type: article

Abstract: Oculogyric crisis (OGC; also referred to as oculogyric spasm) is a rare movement disorder characterized by tonic conjugate eye deviation, typically upward, with preserved consciousness.Associated features include blepharospasm, cervical dystonia, autonomic manifestations (pupillary dilation, lacrimation), and psychiatric symptoms (anxiety, agitation) 1 .Levodopainduced OGC (LI-OGC) represents sustained tonic deviation, typically appearing 10-30 minutes post-dose, associated with patient awareness and distress 2,3 .On the other hand, levodopa-induced ocular dyskinesia (LIOD) differs fundamentally: brief phasic eye deviations lasting seconds, with patients usually unaware and untroubled by the movements 3 .

Source: Journal of Movement Disorders

DOI: 10.14802/jmd.26021

Authors: Oybek Turgunkhujaev, Elina Bagdasarova, Shen-Yang Lim

Institutions: State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan, University of Malaya

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7140638905