Work

Addisonian crisis following osteoprotective therapy in a patient with secondary adrenal insufficiency

Year: 2026

Type: article

Abstract: Addisonian crisis secondary to parenteral therapy with zoledronic acid has been rarely reported in the literature. The case report herein presents a case of a 27-year-old female patient with a known history of panhypopituitarism and secondary adrenal insufficiency who developed an Addisonian crisis following her first intravenous infusion of zoledronic acid. This highlighted the role of zoledronic acid as a potential trigger. This is probably mediated by an acute-phase reaction with the lack of a sufficient cortisol response. Therefore, close monitoring of patients with adrenal insufficiency undergoing osteoprotective therapy, at least during the first administration, is indeed recommended.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luag005

Authors: Al Hossain Al Nour, Shaymaa Elgaafary, Pauline Rink, Judith Pannier, Gerhard Behre

Institution: Städtisches Klinikum Dessau

Language: English

Topic: Adrenal Hormones and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930