Work

Pseudomyogenic Hemangioendothelioma With Novel NEDD9::FOSB Fusion Gene

Year: 2026

Type: article

Abstract: Pseudomyogenic hemangioendothelioma (PMHE) is a rare, low-grade vascular neoplasm that presents cutaneously as erythematous papules or nodules. Diagnosis is challenging, as PMHE can mimic more common benign dermatological conditions and shares histological similarities with high-grade tumors, particularly epithelioid sarcoma. We present the case of an 18-year-old male with a two-year history of a tender, indurated, dark brown subcutaneous plaque on his right upper thigh with histopathologic features consistent with PMHE. Genetic testing revealed a novel gene fusion, NEDD9::FOSB, which has not previously been reported in the literature, adding to the current genetic understanding of PMHE, and warrants further exploration as a potential therapeutic target.

Source: Pediatric Dermatology

DOI: 10.1111/pde.70190

Authors: Suchita Sampath, Cathleen D'Angelo, Archana Shenoy, Ashlie Rubrecht, Jennifer H. Aldrink, Esteban Fernandez Faith

Institutions: Riverside Methodist Hospital, Ohio University, Nationwide Children's Hospital, The Ohio State University

Language: English

Topic: Vascular Tumors and Angiosarcomas

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7140660643