Work

Macrophage Efferocytosis in Heart

Year: 2026

Type: article

Abstract: Efficient clearance of dying cells by efferocytosis is critical for organ development, inflammation resolution, and tissue repair. In the heart, the stakes of efficient clearance are high in that inefficient efferocytosis promotes an inflammatory environment that stresses the health of surrounding nonregenerative cardiomyocytes. Herein, we discuss the fundamental protagonists and therapeutic implications of efferocytosis within the myocardium during cardiac development, myocardial regeneration, and myocardial infarction.

Source: Arteriosclerosis Thrombosis and Vascular Biology

DOI: 10.1161/atvbaha.125.323209

Authors: Hiroyasu Inui, Xiangyu Yu, Eric Pfrender, Joseph Bednarek, Lei Zhang, Edward B. Thorp

Institutions: Northwestern University, China Pharmaceutical University, Lurie Children's Hospital

Language: English

Topic: Phagocytosis and Immune Regulation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health