Basophils drive the resolution and promote wound healing in adult and aged mice
Year: 2026
Type: article
Abstract: An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils accumulate in perivascular areas at the periphery of mouse skin wounds for at least 3 wk, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis. These properties are particularly driven by basophil-derived IL-4. Unexpectedly, aged mice basophils more potently infiltrate skin wounds to promote inflammation resolution. Thus, basophils are pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly.
DOI: 10.1084/jem.20240764
Authors: Julie Bex, Victoria Peter, Chaimae Saji, Claire Dupont, Mathilde Lavernhe, Suoqin Jin, Léa Chapart, Gregory Gautier, Olivier Thibaudeau, Morgane K. Thaminy, John Tchen, Quentin Simon, Xing Dai, Kensuke Miyake, Hajime Karasuyama, Jean X. Jiang, Karmella Naidoo, Marc Benhamou, Ulrich Blank, Renato C. Monteiro, Graham Le Gros, Agnès Coste, Nicolas Charles, Christophe Pellefigues
Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Centre de Recherche sur l'Inflammation, École Nationale Vétérinaire de Toulouse, RESTORE, Université de Toulouse, Wuhan University, Fédération de recherche en imagerie multi-modalité, Inovarion (France), University of California, Irvine, Institute of Science Tokyo, The University of Texas at San Antonio Health Science Center, Malaghan Institute of Medical Research, Victoria University of Wellington
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Dr Marjorie Barclay Trust, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Centre National de la Recherche Scientifique, Université de Paris, National Institutes of Health, National Outstanding Youth Science Fund Project of National Natural Science Foundation of China, Health Research Council of New Zealand
OpenAlex ID: W7140698941