Streamlined One‐Pot Synthesis of Fused Pyrroles: A Three‐Component Approach
Year: 2026
Type: article
Abstract: New modified pyrrole derivatives, namely tetrahydroindol-4-ones and pyrrolo[2,3-d]pyrimidines, functionalized at position 3, were synthesized through a one-pot multicomponent condensation. Stabilized dimedone enaminones derived from α-amino acids and their esters (or 6-amino-1,3-dimethyluracil), arylglyoxals, and methylene-active compounds (malononitrile, Meldrum's acid) were selected as key reagents for the reaction. Functionalization of 3-cyanoacetamides within the 4,5,6,7-tetrahydroindol-4-one framework was performed, involving transformations of the cyanoamide fragment, carbonyl group, and acetate residue at position 1 of the bicyclic system. The reactions proceeded under mild conditions, without the use of hazardous organic solvents or catalysts. Multicomponent condensation approach is particularly attractive for such syntheses, as it offers high atom economy, operational efficiency, and enables the rapid construction of structurally diverse and complex molecules in a single synthetic operation, thereby affording good yields with straightforward purification.
Source: ChemistryOpen
DOI: 10.1002/open.70181
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,790
OpenAlex ID: W7140732838