Work

Malignant Transformation of Oral Epithelial Dysplasia in Southern Finland

Year: 2026

Type: article

Abstract: BACKGROUND: Oral epithelial dysplasia (OED) often precedes oral squamous cell carcinoma (OSCC). The aim was to elucidate the risk and time of malignant transformation (MT) of OED. METHODS: Patients diagnosed with OED between 2001 and 2011 in Helsinki and Uusimaa, Finland were included. Kaplan-Meier and Cox proportional hazard analysis factors associated with the MT time. RESULTS: Dysplasias of 225 patients (mean age 60.0 years, 51.6% females) were diagnosed as mild (85.8%), moderate (11.6%), or severe (2.7%). MT occurred in 14.7% (51.5% females, 48.5% males) at a median time of 5.5 years (IQR 1.7-12.5 years). MT occurred in 33.3% of severe (n = 6), 34.6% (n = 26) of moderate, and 11.4% (n = 193) of mild dysplasia. Dysplasia severity was associated with an increased risk for MT. CONCLUSIONS: MT of OED was 14.7%. The severity of OED is a predictor for MT.

Source: Head & Neck

DOI: 10.1002/hed.70241

Authors: Katariina Leino, Hanna K. Laine, Ville Kinnula, Jaana Rautava

Institutions: University of Helsinki, Helsinki University Hospital

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,760