Work

Omega-6/omega-3 oxylipin imbalance and altered 15-LOX and sEH pathways in Fontan physiology

Year: 2026

Type: article

Abstract: Fontan patients exhibit a distinct oxylipin signature characterized by markedly elevated total and ω-6-derived oxylipins, including increased 15-LOX activity and higher sEH product-to-substrate ratios, alongside reduced ω-3 species such as 20-hydroxydocosahexanoic acid (20-HDoHE) and 17,18-dihydroxyeicosatetraenoic acid (DiHETE). Elevated ω-6 oxylipins correlated with poorer exercise capacity, greater frailty, and impaired hemodynamics, whereas ω-3 oxylipins showed the opposite trend. These findings identify oxylipin dysregulation as a central metabolic hallmark and potential therapeutic target in Fontan circulation.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00901.2025

Authors: Stephanie P. B. Caligiuri, Amir Ravandi, Harold M. Aukema, Ashish H. Shah

Institutions: William & Mary, St. Boniface Hospital, University of Manitoba

Language: English

Topic: Congenital Heart Disease Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7140734565

FWCI: 8.943

Cites: 45

Cited by: 2

Related to: