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Recalcitrant Perioral Dermatitis Successfully Controlled With Low-Dose Isotretinoin: A Case Report

Year: 2026

Type: article

Abstract: We report the case of a 45-year-old woman with recalcitrant perioral dermatitis resistant to multiple topical and systemic therapies who achieved complete remission following treatment with oral isotretinoin. The patient presented with persistent periorificial papules despite ivermectin-based topical regimens, calcineurin inhibitors, compounded anti-inflammatory formulations, and repeated courses of doxycycline. Sustained disease control was achieved with low-dose isotretinoin maintenance therapy. This case highlights the therapeutic challenges associated with refractory perioral dermatitis and supports the potential role of isotretinoin as an antibiotic-sparing strategy in selected patients.

Source: Cureus

DOI: 10.7759/cureus.105896

Authors: Diego Guarda, Priscilla Marquez, Gerardo Bascuñan, Catalina Montane

Institutions: Universidad Andrés Bello, Universidad de Santiago de Chile

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7140830657

FWCI: 6.508

Cites: 10

Cited by: 1

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