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circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Year: 2026

Type: article

Abstract: studies demonstrated that circOMA1 was transported via exosomes, facilitating the transmission of CAB resistance among PRL‑PitNET cells. Plasma exosomal circOMA1 levels were significantly elevated in PRL‑PitNET patients preoperatively. These findings established circOMA1 as a key mediator of CAB resistance and a potential prognostic indicator in patients with a PRL‑PitNET.

Source: International Journal of Molecular Medicine

DOI: 10.3892/ijmm.2026.5812

Authors: Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu

Institutions: Sun Yat-sen University, Sixth Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7140849569

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