Work

Identifying Priority Outcomes for Mothers and Babies in Pregnancies With Preterm Pre‐Labour Rupture of Membranes for Future Clinical Trials

Year: 2026

Type: article

Abstract: Preterm pre-labour rupture of membranes (PPROM) is associated with neonatal and maternal morbidity and mortality. Maternal prophylactic antibiotic therapy after PPROM improves outcomes but there is limited evidence to guide the optimal antibiotic regimen. This study surveyed 45 women with PPROM to understand consumer priorities for care, maternal and neonatal outcomes; and inform future PPROM clinical trial design. The highest priorities were prolonging gestation, avoiding brain injury, improving neonatal survival and good childhood respiratory health. Seventy-nine percent of respondents would consider clinical trial participation. Identifying consumer priorities will support both trial design and improved clinical care.

Source: Australian and New Zealand Journal of Obstetrics and Gynaecology

DOI: 10.1111/ajo.70112

Authors: Ahalya Sathiyaselvan, Lisa Dawes, Nadia Olivier, Brett J. Manley, Katie Groom, Clare L. Whitehead

Institutions: University of Auckland, Royal Women's Hospital, The University of Melbourne

Language: English

Topic: Preterm Birth and Chorioamnionitis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,920