Septoria tritici blotch resistance gene Stb15 encodes a lectin receptor-like kinase
Year: 2025
Type: article
Abstract: Septoria tritici blotch (STB), caused by the Dothideomycete fungus Zymoseptoria tritici, is one of the most damaging diseases of bread wheat (Triticum aestivum)$^{1}$ and the target of costly fungicide applications$^{2}$. In line with the fungus’s apoplastic lifestyle, STB resistance genes isolated to date encode receptor-like kinases (RLKs) including a wall-associated kinase (Stb6) and a cysteine-rich kinase (Stb16q)$^{3,4}$. Here we used genome-wide association studies on a diverse panel of 300 whole-genome shotgun-sequenced wheat landraces (WatSeq consortium$^{5}$) to identify a 99-kb region containing six candidates for the Stb15 resistance gene. Mutagenesis and transgenesis confirmed a gene encoding an intronless G-type lectin RLK as Stb15. The characterization of Stb15 exemplifies the unexpected diversity of RLKs conferring Z. tritici resistance in wheat.
DOI: 10.5167/uzh-433455
Authors: Hafeez, Amber N., Chartrain, Laetitia, Feng, Cong, Cambon, Florence, Clarke, Martha, Griffiths, Simon, Hayta, Sadiye, Jiang, Mei, Keller, Beat, Kirby, Rachel, Kolodziej, Markus C., Powell, Oliver R., Smedley, Mark A., Steuernagel, Burkhard, Xian, Wenfei, Wingen, Luzie U., Cheng, Shifeng, Saintenac, Cyrille, Wulff, Brande B. H., Brown, James K. M.
Language: English
Subfield: Plant Science
Domain: Life Sciences
SDG: Zero hunger
Open Access status: green
OpenAlex ID: W7141084232
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