Work

Divergent Thioamide Synthesis via Umpolung C–N Bond Formation from Nitroethane in Aqueous Medium

Year: 2026

Type: article

Abstract: We present a diverse synthesis of thioamides by installing elemental sulfur and amines in nitroethane via umpolung C-N bond formation. The uniqueness of this water-based protocol renders it more convenient for thioamide synthesis at room temperature. These mild reaction conditions ensure wide functional group tolerance, facilitating late-stage functionalization of drug scaffolds, including intermediates relevant to active pharmaceutical ingredient synthesis.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02880

Authors: Padam Raj Bhatt, Ankush Gupta, Himanshi Sharma, Priyamvada Singh, Brijesh Rathi

Institution: University of Delhi

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: University of Delhi, Science and Engineering Research Board

Award: G755490383