Effect of tetrabenazine on Stroop interference in Huntington’s disease: Protocol
Year: 2026
Type: article
Study design: Study Protocol
Abstract: Objective Tetrabenazine has been shown to improve gating of abnormal visual stimuli and improve postural stability in Huntington’s disease (HD) patients as measured by computerized dynamic posturography testing. This open label pilot study aims to elucidate whether partial dopaminergic depletion via low dose tetrabenazine has a similar effect on masking out of abnormal visual stimuli on the Stroop interference test in HD patients. The study endpoint is the Golden formula calculated from off and on tetrabenazine Stroop test raw scores. Results Full data set was available from one subject with Stroop interference score -1.97 off tetrabenazine and -1 on tetrabenazine, with lower scores showing more interference. The data was not amenable to statistical analysis. A proposed statistical analysis is presented which may be useful to researchers seeking to utilize the methodology.
Source: MethodsX
Author: Robert Fekete
Institution: New York Medical College
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,260
OpenAlex ID: W7141171458