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A Double-Edged Puzzle: Diagnostic Challenges in Herpes-Triggered Erythema Multiforme and Methotrexate Oral Toxicity.

Year: 2026

Type: article

Abstract: A 56-year-old female on long-term methotrexate presented with painful oral ulcerations diagnosed as erythema multiforme. Despite continued methotrexate use, lesions resolved with acyclovir and corticosteroids, confirming herpes simplex virus-associated erythema multiforme. This case highlights the importance of therapeutic response in distinguishing viral triggers from drug-induced causes for accurate management.

Source: Cumhuriyet Dental Journal

DOI: 10.7126/cumudj.1821262

Authors: Smruti Mohapatra, Shilpiranjan Mishra, Atul Bajoria, Jitendra Sharan

Institution: All India Institute of Medical Sciences Bhubaneswar

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7141197641

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Cites: 8

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