No association between troponin and COPD without cardiovascular influence: findings from a population-based cohort (SCAPIS)
Year: 2026
Type: article
Study design: Observational Study
Abstract: Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI -0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.
Source: Thorax
Authors: Jonas Eriksson Ström, Ida Pesonen, Per Liv, Anders Andersson, Apostolos Bossios, Arne Egesten, Magnus Ekström, Jan Engvall, Elin Good, Ola Hammarsten, Jonas Holm, Christer Janson, Åse Johnsson, Lars Lind, Eva Lindberg, Anders Lindén, Andrei Malinovschi, Anna Moberg, Ulf Nilsson, Emma Palmqvist, Magnus Skold, Josefin Sundh, Hanan A Tanash, Suneela Zaigham, Anders Blomberg
Institutions: Umeå University, Karolinska University Hospital, Karolinska Institutet, Sahlgrenska University Hospital, University of Gothenburg, Lund University, Skåne University Hospital, Linköping University, Linköping University Hospital, Uppsala University, Region Västra Götaland, Örebro University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7141236374