Associations between dietary patterns and diabetes in patients with acute pancreatitis: a cross-sectional analysis from the DREAM study
Year: 2026
Type: article
Abstract: BACKGROUND: Dietary patterns have been associated with altered risk of diabetes mellitus (DM) in the general population. These patterns can estimate habitual intake of food groups associated with decreased or increased (e.g., greater intake of red meats) risk of DM. OBJECTIVE: This analysis aimed to examine the underexplored associations of four dietary patterns in patients presenting with an acute pancreatitis (AP) diagnosis based on the presence of pre-existing DM. METHODS: Study participants were selected from the Diabetes RElated to Acute Pancreatitis and its Mechanisms (DREAM) study, an ongoing, multicenter study of adults (18–75 years) with AP in the US. This is a cross-sectional analysis of baseline data collected using the VioScreen computer-administered Food Frequency Questionnaire. We examined four dietary patterns: the Alternate Mediterranean Diet (AMED), the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND), the Healthy Eating Index-2020 (HEI-2020), and the Alternate Healthy Eating Index-2010 (AHEI-2010). Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: The study population included 647 individuals with AP (mean (SD) baseline age, 49.1 (14.5) years). Participants in the highest tertile of dietary index scores were more likely to be older, female, non-Hispanic White, and to have higher educational attainment. In multivariable analyses, greater adherence to the AMED and the MIND dietary patterns was associated with lower odds of pre-existing DM. Multivariable ORs for the odds of pre-existing DM comparing the highest to lowest tertile of diet scores were 0.44 (95% CI: 0.23, 0.84; P-trend = 0.01) for AMED, 0.46 (95% CI: 0.26, 0.82; P-trend = 0.01) for MIND, indicating lower odds for participants with a healthier dietary pattern. CONCLUSIONS: In this analysis, greater adherence to selected healthy dietary patterns was associated with lower odds of pre-existing DM at the time of AP presentation.
Source: Nutrition Journal
Authors: Djibril M. Ba, Tian Qiu, Nazia Raja-Khan, Sun Qi, Fred Tabung, Kristen M. Roberts, Anna E. Phillips, Cemal Yazici, Dhiraj Yadav, Elham Afghani, Venkata S. Akshintala, Marina Basina, Melena Bellin, James L. Buxbaum, Anna Casu, Kathleen Dungan, Carmella Evans-Molina, Evan L. Fogel, Chris E. Forsmark, Mark O. Goodarzi, Brian T. Layden, Sandra Lord, Stephen J. Pandol, Georgios I. Papachristou, Walter G. Park, Richard Pratley, Vikesh K. Singh, Cate Speake, Frederico G. S. Toledo, Guru Trikudanathan, Vernon M. Chinchilli, Phil A. Hart, Darwin L. Conwell, Jeffrey Easler, Steven Hughes, Rajesh Keswani, Ece Mutlu, Temel Tirkes
Institutions: Pennsylvania State University, Harvard University, The Ohio State University Wexner Medical Center, The Ohio State University, UPMC Health System, University of Pittsburgh Medical Center, University of Illinois Chicago, Jesse Brown VA Medical Center, Johns Hopkins Medicine, Johns Hopkins Hospital, Stanford Medicine, Stanford University, University of Minnesota, University of Southern California, AdventHealth Orlando, AdventHealth, Indiana University Indianapolis, University of Florida Health, University of Florida, Cedars-Sinai Medical Center, Benaroya Research Institute, University of Pittsburgh
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
Awards: Dietary Predictors of New-Onset Diabetes following Acute Pancreatitis in the DREAM Study., The Stanford Clinical Center for the Study of Type 1 Diabetes in Acute Pancreatitis, Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus, Cedars Sinai Clinical Center of the Type 1 Diabetes in Acute Pancreatitis Consortium, Type 1 Diabetes in Acute Pancreatitis Consortium – Pacific Northwest Clinical Center: Immune Pathogenesis of Post-Pancreatitis T1D, Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics, University of Minnesota Clinical Center for the Study of Acute Pancreatitis and Diabetes, Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis Consortium, Indiana University clinical Center for acute pancreatitis and diabetes clinical research network
OpenAlex ID: W7141273593