Work

Ameliorating Effects of Phlomis umbrosa Turcz. Root in Ovalbumin-Induced Allergic Asthma: Modulation of IL-33-Mediated Inflammation and TGF-β/Smad-Dependent Fibrosis

Year: 2026

Type: article

Abstract: Turcz. (EPT) herb and its associated bioactive compounds in an ovalbumin (OVA)-induced allergic asthma mouse model. We used phytochemical analysis and identified sesamoside, shanzhiside methyl ester, 8-O-acetyl shanzhiside methyl ester, and isoacteoside as the bioactive components. We validated and quantitatively analyzed shanzhiside methyl ester as a major compound. The treatment with EPT significantly attenuated the T helper type 2 (Th2)-based immune response, eosinophilia, histopathological changes, and biochemical parameters. Furthermore, EPT inhibited interleukin (IL)-33-mediated activation of the nuclear factor kappa B (NF-κB) and transforming growth factor beta (TGF-β) signaling pathways, as well as reduced fibrosis and apoptosis associated with inflammation. The findings of our study suggest that EPT is a promising natural substance for alleviating symptoms of allergic asthma.

Source: Antioxidants

DOI: 10.3390/antiox15040420

Authors: Yeong Hyeon Ju, Hyo Lim Lee, Hye Ji Choi, Yu Mi Heo, Hwa Rang Na, Ho Jin Heo

Institution: Gyeongsang National University

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499