Enhanced meta ensemble stacking approach with XGBoost and optuna based detection of Parkinson's disease
Year: 2026
Type: article
Abstract: Parkinson's disease (PD), a progressive neurological disorder affecting motor function, has been significantly rising in prevalence in recent years. Current diagnostic methods, relying on clinical observations, neurological exams, and periodical DaTscan imaging, may exhibit reduced sensitivity in the early stages. To develop a robust and multimodal machine learning model for early detection, an Ensemble Approach (ESDRCX) is proposed that integrates a meta-ensemble stacking technique that incorporates Decision Tree, Support Vector Machine (SVM) and Random Forest using quantitative data, along with a Convolutional Neural Network (CNN) for spiral image input. Additionally, the outputs are merged using XGBoost as the meta-learner optimized with Optuna-based Tree-structured Parzen Estimator (TPE). The ESDRCX attains a prominent 95.7% accuracy, 86% precision, 91% recall, 88.6% F1-score and 87% AUC with the HandPD dataset, denoting a significant progress in Parkinson's disease diagnostics. The proposed framework delivers an accurate, interpretable and computationally effective approach for early PD detection.
Source: Frontiers in Digital Health
Institution: Vellore Institute of Technology University
Language: English
Subfield: Health Information Management
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,077
OpenAlex ID: W7141425406