Work

A Miniaturized and Modular Wearable Functional Near-Infrared Spectroscopy (fNIRS) Sensing Module for High-Density Cerebral Hemodynamic Monitoring

Year: 2026

Type: article

Abstract: This study presents a modular and scalable wearable functional near-infrared spectroscopy (fNIRS) system for high-resolution cerebral hemodynamic signal acquisition. The system is based on compact optoelectronic modules and supports mixed measurements using short-separation and long-separation channels, offering good scalability and spatial adaptability. The integrated quartz light guide structure improves optical coupling efficiency between the probe and scalp. A series of in vivo experiments validated system performance. In a forearm arterial occlusion experiment, the system accurately captured concentration changes in oxygenated and deoxygenated hemoglobin during blood flow blockade and reperfusion, with large effect sizes (Cohen’s d > 0.9). In a prefrontal cortex Valsalva experiment, the biphasic response characteristic of neurovascular coupling was successfully resolved. In a 2-back working memory task, the system identified a task-related frequency component (0.0227 Hz) and right-lateralized prefrontal cortex activation (p = 0.023). These results demonstrate that the system exhibits a good signal-to-noise ratio and temporal dynamic response, enabling high-resolution mapping of regional hemodynamic changes. This work provides an effective solution for the development of wearable, modular, and high-precision multi-channel fNIRS systems.

Source: Biosensors

DOI: 10.3390/bios16040192

Authors: Mengjie Fang, Xinlong Liu, Bowen Ji, Le Li, Kunpeng Gao

Institutions: Donghua University, Northwestern Polytechnical University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,654