Year: 2026
Type: article
Abstract: Natural selection has, over millions of years, curated a diverse portfolio of species with exceptional lifespans and pron o u n ce d re s i st a n ce to a ge -re l a te d diseases.Moving beyond traditional models to incorporate these "non-model" organisms into our research arsenal is no longer optional but essential for a holistic understanding of longevity.Rather than viewing these species in isolated, descriptive contexts, the Longevity Intelligence framework treats them as fundamental data generators -naturally occurring experiments in delayed aging that provide the critical input data required for advanced computational modeling.The bowhead whale: As the longest-lived mammal on Earth, with lifespans reliably estimated to exceed 200 years, the bowhead whale stands as a paramount example of negligible senescence in nature.This species exhibits a remarkable, near-complete resistance to cancer and other common age-related pathologies.Genomic comparative studies have pinpointed specific genes under significant positive selection in the bowhead whale, which are core components of DNA repair machinery, cell cycle regulation, and tu-Artificial intelligence and multiomics for longevity across species
Source: Element
Authors: Chao Nie, Zhiyuan Shi, Zijun Song, Fudi Wang, Junxia Min
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7141427624