Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil
Year: 2026
Type: article
Abstract: Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community-acquired and healthcare-associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest country, remain lacking. We performed a retrospective and prospective large-scale surveillance of clinical, veterinary, and community isolates to identify hypervirulent and resistant K. pneumoniae. Among 1,008 isolates screened, one strain (ID_074_25) met hvKp criteria, displaying key virulence loci. Whole-genome sequencing confirmed its genomic features, including a novel sequence type and a novel cluster in NCBI Pathogen Detection tool. This study underscores the need for national surveillance and capacity-building in reference laboratories.
Source: Microbiology and Immunology
Authors: Carlos Henrique Camargo, Ana Beatriz Nascimento Costa, Amanda Yaeko Yamada, Daniel de Sena Miranda, Pedro Smith Pereira Ferraro, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Rafaela Mastrangelo Rissetti, Carolina Lechinski de Paula, Patrik Júnior de Lima Paz, Maria Solange Duarte Soares, Christiane Salvador, Giovanna de Pinho Pieri, Jorge Siguemassa Higa, Daniela dos Santos Souza, Márcio Garcia Ribeiro, Claudio Tavares Sacchi, Monique Ribeiro Tiba‐Casas, Geraldine Madalosso, Denise Brandao de Assis
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,750
Awards: G1261296547, Multi-User Equipment approved in grant 2017/50333-7: MALDI-TOF, G3817527101, G4025847860, G4556892877, G4559992073, Institutional research development plan of the Instituto Adolfo Lutz (PDIp), Multi-user equipment approved in grant 2017/50333-7: genetic analyzer, G6199839806, G7624786086, G8091411297, G8449934842
OpenAlex ID: W7141443760