Work

Unicentric Pulmonary Castleman Disease Mimicking Lung Cancer: A Case Report

Year: 2026

Type: article

Abstract: Castleman disease (CD) is a rare lymphoproliferative disorder typically involving mediastinal lymph nodes. Pulmonary involvement without mediastinal lymphadenopathy is extremely rare and often mimics lung cancer. A 76-year-old man presented with an incidental left upper lobe opacity that progressed over 3 years to a 29 mm heterogeneous enhancing nodule. Surgical resection revealed hyaline vascular unicentric CD with characteristic pathology. The patient remained disease-free at 24 months. Pulmonary CD should be considered in enlarging lung nodules with enhancement and no mediastinal lymphadenopathy.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70559

Authors: Mingming Xu, Qing Zhang, Luyan Yin, Jianle Chen

Institutions: Nantong University, Affiliated Hospital of Nantong University

Language: English

Topic: Lymphadenopathy Diagnosis and Analysis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130