Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide A laboratory experiment was developed to enable students to synthesize Ravicti, a drug used to treat Urea Cycle Disorders (UCDs). In response to legislation restricting the use of dichloromethane (DCM), otherwise known as methylene chloride, this synthesis uses cyclopentyl methyl ether (CPME) as a less hazardous, hydrophobic ether solvent. When implemented with students, they synthesized Ravicti in good yield and purity while discussing the adaptations to the traditional process together with the underlying reaction mechanisms. Students also determine relevant green metrics such as process mass intensity, which they use to quantify and explain the greenness of the conventional and adapted procedures.
Source: Journal of Chemical Education
Institutions: University of York, Augsburg University, University of Augsburg
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7141471217