Work

Cobalt-Catalyzed Three-Component Reductive Coupling of Aldehydes, Allenes, and Aryl Halides

Year: 2026

Type: article

Abstract: A Co-catalyzed reductive three-component coupling of aldehydes, allenes, and aryl halides is described. The reaction is both regio- and stereoselective and produces stereodefined trisubstituted alkenylsilanes that can be converted into trisubstituted alkenes. Broad functional group tolerance was demonstrated through 40 examples, with an oxidative addition mechanism proceeding through halide abstraction.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c00927

Authors: Joshua D. Sieber, Magdalene Togoh, Sara Azad, TyAnn McHenry, Murell Sanders

Institution: Virginia Commonwealth University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, Division of Chemistry