Work

Iron-Catalyzed Site-Selective γ-C(sp 3 )-H Azidation of Hydroxylamine Derivatives

Year: 2026

Type: article

Abstract: )-H azidation that proceeds with exclusive γ-selectivity relative to the carbonyl group via a 1,5-hydrogen atom transfer process initiated by an iron-nitrenoid species. This strategy, based on the combination of hydroxylamine derivatives and trimethylsilyl azide with a simple iron catalyst, provides efficient access to a broad range of azido-amide and azido-carbamate products.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.6c00087

Authors: Hugo Esteves, Tania Xavier, Guillaume Prestat, Farouk Berhal

Institutions: Centre National de la Recherche Scientifique, Université Paris Cité, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Centre National de la Recherche Scientifique

OpenAlex ID: W7141526423

FWCI: 3.756

Cites: 36

Cited by: 2

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