CORONATE: A Novel Questionnaire to Assess the Long-Term Impact of Psoriasis on Patients’ Lives
Year: 2026
Type: article
Study design: Observational Study
Abstract: Introduction: Psoriasis has a profound impact on patients’ quality of life, affecting their emotional well-being, social interactions, and career choices. However, current assessment tools fail to capture the long-term burden of psoriasis. Objective: The aim of this study was to develop the CORONATE questionnaire, designed to assess the lifelong impact of moderate-to-severe psoriasis on patients' lives. Methods: A multicenter cross-sectional study was conducted in 15 Italian dermatology centers. This study included 300 patients (age ≥30 years) diagnosed with moderate-to-severe psoriasis (PASI ≥10 or PASI <10 with involvement of sensitive areas). The CORONATE questionnaire, initially consisting of 25 items, was refined through factor analysis. Exploratory and confirmatory factor analyses were performed. Results: The final questionnaire included 18 items grouped into two dimensions: "Work Issues" (5 items) and "Psychosocial Life" (13 items). Factor analysis confirmed strong internal consistency (Cronbach’s alpha: Work Issues = 0.81; Psychosocial Life = 0.91). The model showed excellent fit indices (χ² (153) = 6956.471, P<0.001; Comparative Fit Index = 0.998; Tucker-Lewis Index = 0.998; Standardized Root Mean Square Residual = 0.053). Conclusion: The CORONATE questionnaire is a reliable tool for assessing the cumulative burden of psoriasis. Its implementation in clinical practice may improve personalized patient care.
Authors: Stefano Piaserico, Francesca Sampogna, Martina Accorinti, Paolo Amerio, Claudio Bonifati, Alexandra M.G. Brunasso, Martina Burlando, Christian Ciolfi, Andrea Conti, Sara Di Fino, Maria Esposito, Gennaro Marco Falco, Maria Concetta Fargnoli, Caterina Foti, Paolo Gisondi, Dario Graceffa, Claudio Guarneri, Marika Iarrera, Francesco Loconsole, Anna Levi, Alessia Lozito, Daria Nucciarelli, Giulia Nunziati, Anna Maria Offidani, Aurora Parodi, Pietro Perini, Lucia Peterle, Francesca Prignano, Simone Ribero, Paolo Romita, Francesca Satolli, Marina Venturini, Barbara Zucchi, Clara De Simone
Institutions: University of Padua, Istituto Dermopatico dell'Immacolata, Istituti di Ricovero e Cura a Carattere Scientifico, University of Turin, University of Chieti-Pescara, San Gallicano Hospital, Ospedale Villa Scassi, Ospedale Policlinico San Martino, Ospedale Infermi di Rimini, University of L'Aquila, Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, University of Bari Aldo Moro, University of Verona, University of Messina, Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari, University of Florence, Marche Polytechnic University, University of Parma, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Brescia
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7141526656