Year: 2026
Type: article
Abstract: Introduction.- Affordable and accessible Deoxyribonucleic Acids (DNA) detection remains a major challenge in global healthcare because most molecular diagnostic techniques rely on chemical labels, complex reagents, and expensive equipment. Objective.- In this study, we investigate a fundamentally different approach based on Magnetic Induction Spectroscopy (MIS) to detect DNA concentrations in solution without labels, reagents, or physical contact. Methods.- Bulk electrical propertiess of DNA at multiple concentrations informed a three-dimensional electromagnetic simulation model. Results.- Multifrequency analysis revealed clear differences in the inductive phase shift as a function of DNA concentration, with maximum sensitivity near 1 MHz. Conclusions.- Simulated and extrapolated results indicate a potential detection range of 0.06–1000 μMol, encompassing typical post-PCR concentrations. The findings demonstrate modeling-based feasibility for concentration-dependent detection of bulk DNA.
Source: BioTechniques
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,415
OpenAlex ID: W7141550182