Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross‐Relaxation Triggers RASER of Solute Molecules
Year: 2026
Type: article
Abstract: Radiofrequency amplification by stimulated emission of radiation (RASER) is a phenomenon that is observed in systems of nuclear spins with strong inverse polarization beyond the thermal equilibrium. RASER is of fundamental interest and also possesses several features of possible practical importance, such as very narrow NMR lines and background-free detection. However, so far, the effect was limited to molecules directly polarized by corresponding hyperpolarization techniques. In this work, we found that strongly hyperpolarized allylic compounds transferred polarization via nuclear Overhauser effect (NOE) to other solutes, triggering their RASER. In stark contrast to previous observations, the parahydrogen addition and intermolecular NOE transfer engendered RASER (PAINTER) does not require direct hyperpolarization of the target molecule. This way polarized and detected solutes had 10-20 times narrower lines compared to their classical NMR spectra, providing a useful analysis tool for various molecules beyond standard NMR limitations.
DOI: 10.1002/anie.2865398
Institutions: University of Freiburg, University Medical Center Freiburg, Novosibirsk State University, International Tomography Center, Christian-Albrechts-Universität zu Kiel, University Hospital Schleswig-Holstein, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung, Wayne State University, The Barbara Ann Karmanos Cancer Institute
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,510
Awards: G1003206793, G1148067206, G1502266186, G1580916385, G1614854811, G1635174435, G1763745047, Collaborative Research: Using Spin Networks to Enable Next-Generation 'SABRE' Imaging and Polarizing Molecular Systems at Scale, G2149810171, G2184089736, G2819565804, G2899880, G3661132392, Parawasserstoffinduzierte Hyperpolarisation von 13Cmarkierten Ketocarbonsäuren für medizinische Anwendungen: Synthese, Polarisationsübertragung, 13CMRT, G5630156743, G5752782851, G6316168132, G6693189664, G883802833, G890343428, G902585018
OpenAlex ID: W7141652474