Year: 2026
Type: article
Study design: Case Report
Abstract: Liver failure is a critical condition secondary to not only hepatopathy but also extrahepatic etiologies. This article presents a unique case of hyperthyroidism-induced liver failure complicated with Wolff-Parkinson-White syndrome and pneumonia. The 53-year-old male patient had a history of hepatitis B but no prior hyperthyroidism or medication use. He was admitted with jaundice, fever, and palpitations, and underwent one session of therapeutic plasma exchange in the intensive care unit. Other treatments included hepatoprotective agents, blood component transfusions, antithyroid drugs, antiarrhythmic therapy, and antibiotics. Radiofrequency catheter ablation was performed to eliminate an accessory atrioventricular pathway. Within 3 weeks, significant improvement was observed in hepatic, coagulation, thyroid, and cardiac functions. After 6 weeks of intensive care, the patient was transferred to a general ward and discharged on day 52. Follow-up confirmed full recovery without sequelae. In conclusion, early antithyroid drugs and radiofrequency catheter ablation are safe and effective in this case, while radioiodine therapy and glucocorticoids are not essential. Accurate diagnosis and etiological treatment are the keys to managing complex liver failure cases in clinical practice.
Source: Frontiers in Medicine
Authors: Yifan Ke, Yuankai Wu, Yutian Chong
Institution: Third Affiliated Hospital of Sun Yat-sen University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: Sun Yat-sen University
Award: G7419468707
OpenAlex ID: W7141689680