Au-delà de la mémoire sociale : activité de la région CA2 de l'hippocampe lors de la navigation en direction d'une récompense
Year: 2025
Type: dissertation
Abstract: Animals’ survival largely depends on their ability to learn and remember how to navigate towards sites of interest such as food locations or home. The hippocampus is a key brain structure for spatial memory. Hippocampal place cells fire at discrete locations (their place fields) as subjects move through their environment, thereby providing a neural code for current location during locomotion. However, in the CA1 region of the hippocampus, this cognitive spatial map is not homogeneous: several studies indicate that place fields tend to accumulate next to salient cues such as rewards, a process called “goal-oriented remapping”. The mechanisms underlying the establishment of this “biased” map are very little understood. Moreover, whether the often overlooked CA2 region of the hippocampus also presents such map goal-oriented bias and/or contributes to CA1 remapping is unknown.The goal of this PhD project was to characterize the activity of the CA2 region during spatial navigation towards rewards and during reward consumption to test the hypothesis that it participates in biasing the hippocampal cognitive towards salient locations.
Source: theses.fr (ABES)
Author: Spitsyn, Alena
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7141776582
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