Work

Positive association between local brain hypercorrelations and posttraumatic stress disorder symptom severity

Year: 2026

Type: article

Abstract: This study documented that, relative to healthy brain functioning, posttraumatic stress disorder (PTSD) is associated with increased local (intra-area) correlations in the cortex and subcortex. Remarkably, PTSD symptom severity was positively and significantly associated with increased correlations. These findings complement previous research documenting hypercorrelated interactions across brain areas and suggest a potential benefit of interventions aimed at decorrelating brain networks to a normal state.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00597.2025

Authors: Peka Christova, Lisa M. James, Brian E. Engdahl, Apostolos P. Georgopoulos

Institutions: University of Minnesota, Minneapolis VA Health Care System, Minneapolis VA Medical Center

Language: English

Topic: Posttraumatic Stress Disorder Research

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, McKnight Foundation, University of Minnesota