Work

Transcriptional remodeling of human skeletal muscle following sleep restriction in postmenopausal women

Year: 2026

Type: article

Abstract: Sleep restriction triggers coordinated transcriptional remodeling in postmenopausal women, including upregulated oxidative phosphorylation and myogenesis pathways, while suppressing immune and inflammatory signaling. Differential correlation analysis revealed substantial reorganization of gene coexpression networks. Transcription factor YY1 emerged as a key mediator linking sleep loss to metabolic and immune dysregulation in muscle. These findings reveal skeletal muscle's adaptive response to insufficient sleep and identify YY1 as a potential therapeutic target for sleep-related metabolic dysfunction.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00269.2025