Work

Mechanisms of norepinephrine-induced Ca 2+ responses in perivascular adipose tissue

Year: 2026

Type: article

Abstract: Norepinephrine (NE)-induced Ca 2+ signaling in PVAT is mediated by adrenergic receptors with depot-specific roles. All three receptor subtypes contribute in mPVAT and aPVAT, whereas α1a predominates in white adipose tissue. Internal Ca 2+ stores are the primary Ca 2+ source for NE-induced signaling across depots. Ca 2+ imaging with selective agonists supports α1a’s role, and NO imaging highlights depot diversity. Immunofluorescence data confirm receptor expression on adipocytes and vasculature, indicating complex signaling pathways in adipose tissues studied here across depots.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00364.2025

Authors: Julia R. Jamka, Emma D. Flood, William F. Jackson, Brian D. Gulbransen

Institution: Michigan State University

Language: English

Topic: Cardiovascular Disease and Adiposity

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, NHLBI Division of Intramural Research