Work

Predictive modeling of putamen dopamine in Parkinson’s disease: relevance to prognosis, treatment, and prevention

Year: 2026

Type: article

Abstract: We used kinetic modeling to predict the temporal course of putamen dopamine depletion across the lifespan in Parkinson's disease and predict effects of autotoxicity, genetics, environmental exposures, and possible treatments on the timing of the onset of symptomatic disease.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00027.2026

Author: David S. Goldstein

Institutions: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Neurological Disorders and Stroke