Work

Hydrogen transfer-triggered C(sp3)−C(sp3) cleavage of 1,3-diols for mono-N-methylation of primary amines

Year: 2026

Type: article

Abstract: Here, the authors establish 1,3-propanediol, a low-cost biomass-derived bulk chemical, as an efficient, green, and sustainable C1 source for the mono-N-methylation of primary amines, via chelation-free C(sp3)−C(sp3) bond cleavage.

Source: Nature Communications

DOI: 10.1038/s41467-026-71217-1

Authors: Yang Long, Jun Liu, Lei Chen, Jun Dong, Xinhao Fan, Lang Qu, Zhishan Su, Yanling Zheng

Institutions: North Sichuan Medical University, Sichuan University

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: National Natural Science Foundation of China, Sichuan University

Award: G4801562216

OpenAlex ID: W7142473995

FWCI: 1.352

Cites: 64

Cited by: 1

Related to: