Diagnosis and Therapeutic Outcomes of Biopsy-Confirmed Pure Neuritic Leprosy: A Two-Decade Experience.
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background:Pure neuritic leprosy (PNL) is a distinct form of leprosy characterized by peripheral nerve involvement without skin lesions. Diagnosis is often delayed, and ‘silent neuritis’ contributes to progressive and irreversible nerve damage. Despite appropriate therapy, many patients develop long-term disability. This study describes the clinical profile, diagnostic patterns, therapeutic outcomes, and predictors of disability in biopsy-confirmed PNL. Methods:We conducted a retrospective observational cohort study at a tertiary referral centre in South India, enrolling biopsy-confirmed PNL cases from January 2003 to May 2023. Demographic, clinical, electrophysiological, and histopathological data were collected. The primary outcome was the proportion of patients with high disability at follow-up (WHO grade 2 or higher). Predictors of disability were identified using multivariable analysis.
Authors: Sarkar, Shrimantika, Angel Miraclin, Ranjani Jayachandran, Anitha Jasper, Reethu Anny Eapen, Lydia Mathew, Dharshini S, Dincy Peter, Leni George, Harshad Arvind Vanjare, Deepti Bal, Hemalatha, Aditya Nair, Shaikh Atif Iqbal Ahmed, Appaswamy Thirumal Prabhakar, Vivek Mathew, Sanjith Aaron, Susanne Pulimood, Rima Sathyakumar, Geeta Chacko, Ajith Sivadasan
Institution: Christian Medical College, Vellore
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7142527089
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