Work

An L-shaped curve relating Hs-CRP/HDL-C(CHR) index to kidney stone disease (KSD) in US adult participants: a cross-sectional study

Year: 2026

Type: article

Abstract: Using 2015–2020 NHANES data, this cross‑sectional study examined the association between the Hs‑CRP/HDL‑C index (CHR) and adult kidney stone disease (KSD) and its potential nonlinear dose–response pattern. Weighted multivariable logistic regression and spline analyses were applied. Overall KSD risk was 10%; CHR showed a positive association with KSD odds (OR = 1.04, 95% CI = 1.01–1.08, P < 0.05). Smooth curves revealed an L‑shaped relationship (P for nonlinearity <0.05), with a steep increase when CHR <0.358, then plateauing. An interaction with albumin level was observed (P < 0.05); subgroup analyses by age, sex, BMI, smoking, alcohol, and triglycerides showed no significant differences. These findings suggest CHR may aid KSD risk assessment, but prospective studies are needed to confirm causality and temporal sequence.

Source: The Aging Male

DOI: 10.1080/13685538.2026.2650010

Authors: Baolei Shi, Wenbing Yuan, Shuangning Liu, Yu Dai, Xiaoke Sun, Yatao Jia

Institutions: Jieyang People's Hospital, Xi'an Honghui Hospital, Xi'an Jiaotong University

Language: English

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,557