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Site‐Specific Surface Modification via Chemoselective Click Reactions on Cyclobutene‐Functionalized Monolayers

Year: 2026
Type: article
Abstract: We report the first example of self-assembled monolayers (SAMs) incorporating a cyclobutene-substituted alkanethiol on a gold surface and the efficient modification of these monolayers via inverse electron-demand Diels-Alder (IEDDA) cycloadditions. Mixed SAMs incorporating both cyclobutene- and azide-substituted alkane thiols undergo controlled bisfunctionalization through either sequential or simultaneous performance of IEDDA and copper-assisted alkyne/azide cycloaddition (CuAAC) ligations.
DOI: 10.1002/open.202500617
Authors: Boone W. Evans, Kenneth N. Hipp, William D. Lambert, Wantanee Sittiwong, Rebecca Y. Lai, Patrick H. Dussault
Language: English
Field: Chemistry
Open Access status: gold
Estimated APC paid: $2,790
Funders: National Science Foundation, University of Nebraska-Lincoln, National Institutes of Health, Nebraska Center for Integrated Biomolecular Communication, National Institute of General Medical Sciences, National Center for Research Resources
OpenAlex ID: W7143464033
FWCI:
Cites: 34
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Related to: 10