Work

MRBEE-TL: improving causal effect estimation in multi-ancestry multivariable Mendelian randomization with transfer learning

Year: 2026

Type: article

Abstract: Multivariable Mendelian randomization has been largely applied to individuals of European ancestry, due to the larger sample sizes available in European GWAS. We introduce MRBEE-TL, one of the first multi-ancestry multivariable Mendelian randomization methods, which combines transfer learning with bias-corrected estimating equations to improve power in underpowered ancestries and to assess cross-ancestry heterogeneity of disease risk factors. In simulations, MRBEE-TL consistently outperforms MR methods that rely solely on ancestry-specific GWAS data. In real data analyses, MRBEE-TL not only identifies ancestry-consistent and ancestry-specific causal effects missed by conventional methods, but also improves power in underpowered ancestries.

Source: Genome biology

DOI: 10.1186/s13059-026-04051-9

Authors: Yihe Yang, Xiaofeng Zhu

Institution: Case Western Reserve University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,490