Ellipsoid Zone Integrity at Angiographic Leak After Resolution of Central Serous Chorioretinopathy
Year: 2026
Type: article
Study design: Observational Study
Abstract: PURPOSE: This study aimed to explore prognostic factors for predicting ellipsoid zone integrity and its association with angiographic leakage and optical coherence tomography biomarkers at baseline. METHODS: In this multicenter retrospective study, resolved central serous chorioretinopathy (CSCR) eyes with perifoveal angiographic leak at baseline were included. Baseline demographics, clinical features, and anonymized imaging data, including fluorescein angiography, and optical coherence tomography were collected. The leakage site was identified on fluorescein angiography, and its corresponding location on optical coherence tomography was analyzed for structural changes and photoreceptor outer segment elongation. Central macular thickness, subfoveal choroidal thickness, Haller layer thickness, and Haller index (Haller layer thickness/subfoveal choroidal thickness) were measured at baseline and follow-up. Ellipsoid zone (EZ) integrity after resolution was classified as continuous, discontinuous, and atrophic. RESULTS: Eighty four eyes with resolved CSCR were included. Longer symptom duration ( P = 0.032) and complex CSCR ( P = 0.04) were associated with a higher likelihood of atrophic EZ. Significant reductions in central macular thickness, subfoveal choroidal thickness, and Haller layer thickness were observed in all groups, whereas the Haller index significantly reduced only in continuous EZ. Multinominal regression showed significant association between complex CSCR and atrophic EZ. CONCLUSION: Longer symptom duration, complex CSCR, and irregular photoreceptor outer segment thickening are associated with increased risk of EZ atrophy in resolved CSCR. Identifying these risk factors early may help predict visual outcomes and guide patient counselling.
Source: Retina
Authors: Nasiq Hasan, Arman Zarnegar, Hosein Nouri, Stanley Saju, Jessica Cao, Avery Zhou, Charles Wykoff, Priya Shah, Panisa Singhanetr, Elizabeth J. Rossin, Lorenzo F. Desideri, Felicia Hertkorn, Marion R. Munk, Stela Vujosevic, Lisa Checchin, Lorenzo Pili, Maurizio B. Parodi, Carmen Antia Rodriguez-Fernandez, Luis A. Barquet, Michael Zhang, Yusuf Ashfaq, Zachary Kroeger, Min Kim, Lihteh Wu, Jay Chhablani
Institutions: University of Pittsburgh, University of Pittsburgh Medical Center, Isfahan University of Medical Sciences, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences, Houston Methodist, Retina Consultants of Texas, Massachusetts Eye and Ear Infirmary, Harvard University, University Hospital of Bern, Northwestern University, University of Milan, MultiMedica, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Bellvitge University Hospital, Canberra Hospital, Oregon Health & Science University, Yonsei University, Yonsei University Health System
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7143509491