Diurnal Microbial Entrainment Therapy: A Chronobiome-Based Hypothesis for Restoring Metabolic Homeostasis
Year: 2026
Type: article
Abstract: We hypothesize that the scheduled, timed administration of distinct synbiotics-carefully formulated combinations of specific probiotics and prebiotics-can act as a therapeutic zeitgeber to reinforce a health-associated diurnal rhythm within the gut ecosystem.By aligning delivery with physiological peaks and troughs in intestinal bile acid concentration, this intervention seeks to promote a rhythmic microbial community structure.This optimal rhythm is characterized by robust daytime activity of butyrate-producing Firmicutes and synchronized nighttime activity of propionate and acetate-producing Bacteroidetes.The restoration of this phasic activity is predicted to rebuild the beneficial cyclicity of short-chain fatty acid (SCFA) production, thereby recalibrating host metabolic signaling, enhancing gut barrier integrity, and dampening systemic inflammation.
Source: Chronobiology in Medicine
Author: Fahad Basheer
Institution: T. D. Medical College
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7143634759
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