Work

Guselkumab is effective in the treatment of Inverse psoriasis: a case report and literature review

Year: 2026

Type: article

Abstract: Inverse psoriasis is a special type of psoriasis whose pathogenesis is not yet fully understood, and for which there is no consensus guideline due to marked therapeutic challenges associated with the specific anatomic location of lesions. Immune-mediated inflammation plays a key role in its development, and the lesions are susceptible to friction and humidity, which makes the affected area less tolerant to treatment. In this article, we report a successful case of Inverse psoriasis treated with Guselkumab in a 48-years-old male, who was treated with three subcutaneous injections of Guselkumab and exhibited marked improvement in cutaneous lesions and pruritus at 12 weeks of treatment. A review of the relevant literature was also conducted with the aim of providing clinicians with more references for the treatment of this disease.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2026.1789385

Authors: Zhuochen Wu, Xiaoyu Xie, Wenyu Tang, Yifeng Wu, Guoqiang Zhang, Qing Zhu

Institutions: Hebei Medical University, First Hospital of Shijiazhuang, First Affiliated Hospital of Hebei Medical University, Second Hospital of Hebei Medical University

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801