Work

A Case Series on Longitudinal Hypothalamic Morphology in Mild Cognitive Impairment

Year: 2026

Type: article

Abstract: We examined the longitudinal hypothalamic morphology in the progression of mild cognitive impairment (MCI). We used multivariable linear modelling to differentiate the structural volumetric change in the hypothalamic nuclei in nine females who developed MCI after 5 years and 61 healthy controls. We found significantly decreased left anterior-inferior (p<0.01), left anterior-superior (p<0.05), and left posterior (p<0.01) hypothalamic regions among females with MCI compared to healthy controls. There was also a significant asymmetry at the anterior-superior hypothalamus (p<0.05) in MCI females than in healthy controls. Thus, the degradation of the specific left hypothalamic subregions and leftward lateralization over time highlight the impact of early- stage MCI on the morphology of hypothalamus.

Source: Annals of Geriatric Medicine and Research

DOI: 10.4235/agmr.25.0122

Authors: Jeffrey Cayaban Pagaduan, Melvin Barrientos Marzan, Xiaoling Wang, Benjamin Billot

Institutions: The University of Melbourne, Palacký University Olomouc, Augusta University, MIT Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Massachusetts General Hospital