Work

Current landscape and challenges of neuro-oncological molecular tumor boards in Germany: results of a nationwide follow-up survey

Year: 2026

Type: article

Abstract: BACKGROUND: In 2022, a nationwide survey revealed heterogeneity and limited standardization in the implementation of molecular tumor boards (MTBs) for neuro-oncology in Germany. This follow-up study aimed to assess recent developments, structural changes, and the integration of digital tools. METHODS: An anonymous online questionnaire was distributed to approximately 445 members of the German Neuro-Oncology Working Group (NOA). Items focused on MTB availability, frequency, tumor inclusion, recommendation pathways, implementation, digital infrastructure, and perceived barriers. RESULTS: 35 responses were collected. Respondents were primarily experienced neurosurgeons and neurologists working in certified university centers. Most were based in Bavaria, Baden-Württemberg, North Rhine–Westphalia, and Berlin. The number of in-house MTBs increased, with most boards meeting weekly. A broader range of tumor entities—including lower-grade gliomas—and earlier therapy lines are increasingly discussed. Recommendations were issued in fewer than half of cases, and over 30% of proposed therapies were implemented, though often hindered by lack of reimbursement. Virtual tumor boards (50%) and structured databases (40%) are increasingly used, and around 5% of patients are enrolled into national studies. Follow-up strategies and feedback loops remain inconsistent across centers. CONCLUSIONS: MTBs have become more established in neuro-oncology care, reflecting a growing commitment to precision medicine. However, implementation of recommendations remains limited, often constrained by lack of actionable targets, challenges accessing studies or off-label treatments. To fully realize the potential of MTBs, standardized integration pathways, greater harmonization, broader study offerings, and structured evaluation systems are needed.

Source: Journal of Neuro-Oncology

DOI: 10.1007/s11060-026-05549-9